HSP Application note #38
Corresponding State Theory (CST) and Hansen Solubility Parameter (HSP)
HSPiP Team Senior Developer, Dr. Hiroshi Yamamoto
Law of Corresponding State
van del Waals(VDW) equation of state (P + a/v2)(v - b)=RT
a: weak attractive force among molecules
b: volume of exclusion
Input Critical point (Tc, Pc, Vc) to VDW equation.
VDW equation becomes
(Pr + 3/Vr2)(Vr - 1/3)=(8/3)Tr
This equation does not contain molecular specific parameter (a,b)
（Pr=P/Pc, Vr=V/Vc, Tr=T/Tc reduced properties）
Once we know the reduced properties, we can estimate thermo-chemical properties.
Every chemical properties are handled with same scheme. And the scheme does not need molecular specific parameter.
Ex. Vapor Pressure Estimation
Ln ( P / Pc ) = h (1 - 1 / Tr )
h = Tbr * ln(Pc) / (1-Tbr)
P: vapor pressure
Pc: critical pressure
Tc: critical temperature
Tr: measured temperature / Tc (reduced temperature)
Tbr: Boiling point / Tc
P/Pc : Reduced pressure
Boiling point & Critical properties are so important!
Properties estimation JAVA Applets
|Vapor Pressure||Riedel Method|
|Heat of Vaporization||
|Thermal Conductivity||Pirika Neural Network method|
|Viscosity||Pirika Neural Network method|
|Surface Tension||Pirika Neural Network method|
Dipper801 database (1319 compounds)
|Experimental data||Predicted data||Unknown source|
Experimental Critical Properties are hard to get.
High temperature measurement.
Thermal Stability of molecule.
Experimental Critical Properties will not increase any more.
Estimation of Boiling Point and Critical Properties
A lot of critical properties estimation were done, but even estimation of boiling point is still very difficult.
By the way, i am standing the position that Hansen Solubility Parameter is very important properties as thermo dynamics.
And I was asked what is the origin of the Hansen space?
Hansen Solubility Parameters (HSP)
Hansen Solubility Parameters(HSP) were developed by Charles M. Hansen as a way of predicting if one material will dissolve in another and form a solution. They are based on the idea that "like dissolves like" where one molecule is defined as being 'like' another if it bonds to itself in a similar way.
What can perhaps be surprising is that one can assign HSP to so many different things. Gases like carbon dioxide, solids like carbon-60, sugar, and biological materials like human skin, depot fat, DNA, and even some proteins all have HSP. The list can be continued with drugs, polymers, plasticizers, and in fact any organic material and even many inorganic materials like salts. The only requirement for an experimental confirmation is that the material must behave differently in a sufficient number of test solvents upon contact.
Hansen Solubility Parameter or Hildebrand SP are based on heat of vaporization.
And the heat of vaporization of compounds are equal ZERO at critical point.
So the origin of Hansen Space is Critical point.
This means that, the reason we can compare one molecule's HSP vectors to the other, the origin of vectors are both same.
This is the very important point.
The experimental Critical point will not increase anymore.
But HSP is part of Corresponding state theory and good HSP values are increase dramatically.
HSPiP(Hansen Solubility Parameters in Practice)
The first edition of HSPiP that appeared in November, 2008, greatly enhanced the usefulness of the Hansen solubility parameters (HSP).
The HSP values of over 1200++ chemicals and 500 polymers are provided in convenient electronic format and have been revised and updated using the latest data sources in the second edition (March, 2009).
A third edition of the HSPiP appeared in March, 2010. There are now 10,000 compounds in the HSP file which also includes data on density, melting point, boiling point, critical parameters, Antoine constants and much more. The user is able to carry out many different sorts of optimisations of solubility, evaporation, diffusion, adhesion, create their own datasets (automatically if required) and explore the huge range of applications for HSP in coatings, paints, nanoparticles, cosmetics, pharma, organic photovoltaics and much more.
The 3rd Edition v3.1 was released on 12 December 2010. Current users can upgrade free (now v3.1.09) by downloading the latest .msi installer from http://hansen-solubility.com
The 4th Edition v4.0.x was released on 2 Jan. 2013. The Current users can upgrade with free charge.
2013.1.28 The Visual How to manual of HSPiP. You can understand what HSPiP can do.
If you have Smiles structure and HSPiP software, Y-MB function will calculate HSP immediately.
Smiles(Simplified Molecular Input Line Entry Syntax)
SMILES is a string obtained by printing the symbol nodes encountered in a depth-first tree traversal of a chemical graph.
Y-MB Properties Estimation
Y-MB break Smiles into correspponding Functional Groups and Estimate various Properties. These estimation schemes are come from Pirika technologies.
We will show you our HSP base properties estimation results soon.